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Limitations of our study include only recruiting patients after primary MBS surgery (with a small sample size of GB patients)

March 30, 2026 Tirzepatide vs Semaglutide: A Comprehensive Comparison for Providers Share this post Key Takeaways Semaglutide is a GLP-1 receptor agonist, while tirzepatide works on GIP and GLP-1

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In a phase 2 obesity trial, the highest dose led to participants losing an average of 24.2% of their body weight over 48 weeks (a secondary endpoint)

Common Antidepressants: Safety Profile With Semaglutide SSRIs such as sertraline, fluoxetine, and paroxetine are among the most widely prescribed antidepressants, and clinical evidence shows they combine safely with GLP-1 medications including semaglutide